A joint research team from Shanghai University has developed an integrated multi-physics simulation framework combining heat transfer, microstructure evolution, crystal plasticity, and crack propagation, offering a systematic approach for crack analysis and process optimization in laser powder bed fusion (LPBF) and other non-weldable superalloys. The study shows that cracks are initiated by tensile stress during the cooling stage at approximately 200°C. During the propagation stage, fine equiaxed grain boundaries effectively inhibit crack growth, while columnar grains provide continuous propagation paths. Reducing scanning speed promotes the transition from columnar to equiaxed grains, thereby suppressing solid-state cracking. Experimental validation with CM247LC alloy demonstrated a reduction in crack density from 1.35 to 0.05 mm²/mm², a decrease of 96%.