In a study published in Nature Communications on August 13, researchers from the Department of Mechanical and Energy Engineering at Southern University of Science and Technology (SUSTech) demonstrated that mixing CoCrNi and 316L powders, combined with an entropy engineering strategy, enables temporal control of entropy during the LPBF process. This approach produced near-pore-free medium-entropy alloys with relative density exceeding 99.99%. Mechanistically, configurational entropy increases during printing alongside microstructural evolution, optimizing melt pool spreading and thermal history. The result is a stable microstructure dominated by sub-grains with low geometrically necessary dislocation density, yielding superior fatigue resistance and corrosion performance compared to conventional powder bed fusion–processed medium- and high-entropy alloys. Medium- and high-entropy alloys represent a frontier material direction in metal additive manufacturing. This study shows that high-performance medium-entropy alloys can be achieved by blending standard powder grades, offering a new low-cost material pathway. Value for powder buyers: (1) The blended-powder route reduces reliance on customized pre-alloyed medium-entropy powders, potentially increasing demand for conventional CoCrNi and 316L grades. (2) Powder producers may explore service models that combine 'proportional blending with process coupling,' offering customers mixed-powder solutions and process packages. (3) As this is currently at the fundamental research stage, it is advisable to monitor subsequent scale-up validation and engineering application cases.